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KMID : 0356919940270030214
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Korean Journal of Anesthesiology
1994 Volume.27 No. 3 p.214 ~ p.219
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The Effect of Atropine and Neostigmine on the Memory of Rats
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Abstract
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The effect of anticholinergics on memory was studied using 32 male Sprague-Dawley rats. In the control group the trained rats were tested the first performance time of T-maze and the second performance time checked 4-6 hours after injection of
1.0-1.5
mL of normal saline via penile vein. For the experimental groups, after checking the first performance time, 0.1 ㎎/㎏ of atropine sulfate in group B, and 1.0 ㎎/㎏ in group C was injected via penile vein.And 30 ㎎/㎏ injected into
intraperitoneal
cavity in group D, But for the group E. the mixture of 1.0 ㎎/㎏of atropine and 0.01 mg/kg of neostigmine was injected into the penile vein. 4-6 hours after injection the second performance time was checked and continued these sets of experiment
once a
day for 6 days. To compare the number of errors (the qualitative effect) the accuracy rate (Number of right trials/Number of total trials x 100) was checked. To compare the running time (the quantitative effect) the mean performance ratio (Ⅱ/Ⅰx
100)
(i.e., I is the score in the first performance time and Ⅱis the score in the second performance time) was compared between control and experimental groups.
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KEYWORD
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